You will see changes in the way things get delivered.
In New York you will see the couriers having a driver and 2 or 3 guys in the truck who do the running in and out of buildings. The truck keeps moving and even with the extra manpower, their productivity improves.
Smaller stores that are not open during the night will have common receiving areas with other smaller shops to receive their goods.
Home deliveries are not such a big deal since most people prefer their deliveries in the evening anyways.
The large office towers have their own underground receiving areas where trucks are able to deliver to.
In New York, unless you have a reserved parking spot at your office you would not dream of driving to work. Public transit and cheap cabs keep their roads moving in midtown Manhattan way better in does in the GTA.
Many years ago, Toronto did the right thing by pushing for more residential buildings in the downtown core. Hundreds of huge condo's have been built in the past 10 years and tens of thousands of more people live downtown. This is a good thing. It keeps the city alive and revitalizes small business in the city. The problem is that the city is growing at a faster pace than the road system can handle.
I personally believe that this whole "War on traffic" crusade is happening now in order to try to fix the problem before the Pan Am Games which will see downtown traffic levels at a new all time high. If the city is ground to a halt during the weeks of the games it will be a disaster costing hundred of millions of dollars. That I believe is the biggest reason this is happening now, but whatever is done will be too little too late.