I have the Cascadia Evolutions in 2015, 2016, and 2017 models with the DD15's at 455 HP, and DT12 auto-shift transmissions. The "Evolution" moniker denotes the all Detroit drive line which includes the front axle, engine, transmission and rear drives. I have 4 working dry vans and 1 working a roll-tite. All are getting high 9's for fuel mileage ... that's miles per Canadian gallon. Weight-wise they're running about 19,500 lbs, driver in, and full of fuel. Personally, I wouldn't buy any other truck.
I also have 1 Peterbilt model 579 with a Paccar MX-13 engine and an Eaton Ultrashift transmission. It gets almost as good fuel mileage as the Freightliners and has a beautifully appointed cab and bunk which is nicer than the Freightliner offering. Downsides to the Peterbilt are cost of acquisition, and maintenance. Peterbilt's can only be serviced reliably by a Peterbilt dealership ... and their knowledge base is generally quite low when it comes to electronic engines (even their own), and considerably expensive.